天津大学雷圣宾课题组ACS AMI：双功能COF实现抑菌和仿生矿化

(a) Schematic diagram of remineralization of COFTAPB-FPBA-coated acid-etched enamel. (b-i) SEM images of acid-etched enamel treated with COFTAPB-FPBAafter immersion in 1.5×SBF for 1-7 days. (j) COFTAPB-FPBA assisted re-mineralization mechanism of enamels. (k) Hardness and elastic modulus of the natural enamel and COFTAPB-FPBA treated acid-etched enamel after soaking in 1.5×SBF for 7days.

(a) Schematic illustration of the treatment of the enamel by the COFTAPB-FPBA@Honokiol. (b) Ultraviolet-visible (UV-vis) absorption spectra of honokiol, COFTAPB-FPBAand COFTAPB-FPBA @Honokiol. (c) Release profiles of COFTAPB-FPBA@Honokiol. (d) In vitro cell viability of COFTAPB-FPBA and COFTAPB-FPBA@Honokiol against L929 cells after 24 h incubation. (e) The impact of COFTAPB-FPBA@Honokiol on the biofilm of S. mutansfor 48 h was analyzed by laser confocal microscopy (green represents live bacteria, red represents dead bacteria[32]). (f) The ratio between dead and live bacteria was computed by Image J. (g) Growth curves of S. mutans in different groups for 24 h (32 μg/mL COFTAPB-FPBA@Honokiol, 32 μg/mL COFTAPB-FPBA, 32 μg/mL TAPB, 32 μg/mL FPBA, 16 μg/mL honokiol).